Chondrocyte Phenotype and Ectopic Ossification in Collagenase-induced Tendon Degeneration
نویسندگان
چکیده
منابع مشابه
Expression of Bone Morphogenetic Protein-2 in the Chondrogenic and Ossifying Sites of Calcific Tendinopathy and Traumatic Tendon Injury Rat Models
BACKGROUND Ectopic chondrogenesis and ossification were observed in a degenerative collagenase-induced calcific tendinopathy model and to a lesser extent, in a patellar tendon traumatic injury model. We hypothesized that expression of bone morphogenetic protein-2 (BMP-2) contributed to ectopic chondrogenesis and ossification. This study aimed to study the spatial and temporal expression of BMP-...
متن کاملFamilial ectopic ossification.
We report a family with dominantly inherited ectopic ossification. It is characterised by childhood onset of multifocal subcutaneous ossifications (primary osteoma cutis), which are of trivial clinical significance. One family member had extensive ectopic ossification involving one limb. We speculate that this may reflect somatic mutation having caused conversion to homozygosity.
متن کاملExtraskeletal (Ectopic) Calcification and Ossification
A significant number and variety of disorders cause extraskeletal deposition of calcium and phosphate (Table 1). In some, mineral is precipitated as amorphous calcium phosphate or as crystals of hydroxyapatite; in others, osseous tissue is formed. The pathogenesis of ectopic mineralization is generally attributed to one of three mechanisms (Table 1). First, a supranormal “calcium-phosphate solu...
متن کاملEctopic ossification in tuberculous meningitis.
The syndrome of severe wasting, opisthotonus and paraplegia in flexion associated with considerable hydrocephalus is well known to those treating advanced cases of tuberculous meningitis. Once such a condition has developed, the outlook is generally poor. Many patients will die and the survivors will often be handicapped by a variety of physical and mental sequelae. The purpose of this paper is...
متن کاملSustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model.
OBJECTIVES Alteration in the composition of extracellular matrix has been suggested as the major factor for the development of tendinopathy and calcified tendinopathy, which has poorer clinical manifestation. This study investigated the changes of major proteoglycans and collagens in a calcified tendinopathy model and correlated the expression with the acquisition of chondrocyte phenotype, ecto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2008
ISSN: 0022-1554,1551-5044
DOI: 10.1369/jhc.2008.952143